Chamisa is the former chairperson of the MDC Youth Assembly. He was elected MDC spokesman at the Party Congress in June 2006. In April 2011 at the Party’s congress in Bulawayo, he was elected as the Party’s Organising secretary, a post that previously belonged to Elias Mudzuri. In Parliament, he was chair of the portfolio committees of Defence and Home Affairs, Public Accounts, Gender and Youth, and Transport and Communications.
Chamisa is also a member of the Local Government, Public Works & Urban Development, and the African Caribbean and Pacific Parliament. He is a former secretary-general of the Zimbabwe National Students Union.
Chamisa served as a cabinet minister from February 2009 to July 2013, until the end of the Government of national Unity. He also served as the Movement for Democratic Change’s (MDC-T) organising secretary. He lost the position of party Secretary-General in the party’s 2014 Congress to Douglas Mwonzora. Chamisa has been accused of barring other youth and student leaders from having closer access to party president Tsvangirai, a move allegedly meant to protect his position